Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (5): 1127-1138.DOI: 10.6023/cjoc201610034 Previous Articles     Next Articles

Reviews

后过渡金属催化醇对胺的N-烷基化反应研究进展

吴慧, 武俊成, 杜正银   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2016-10-21 修回日期:2017-01-03 发布日期:2017-01-20
  • 通讯作者: 杜正银 E-mail:clinton_du@126.com
  • 基金资助:

    国家自然科学基金(No.21262028)及甘肃省自然科学基金(No.1208RJZA140)资助项目.

Progress in Late Transition Metal-Catalyzed N-Alkylation of Amines with Alcohols

Wu Hui, Wu Juncheng, Du Zhengyin   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2016-10-21 Revised:2017-01-03 Published:2017-01-20
  • Contact: 10.6023/cjoc201610034 E-mail:clinton_du@126.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21262028) and the Natural Science Foundation of Gansu Province (No. 1208RJZA140).

N-Alkylation of amines is a class of important organic reaction. The products of this reaction are related to the important technological fields including chemical, medical, pharmaceutical and defense. In recent years, the development and need of green catalytic synthesis technology make such C-N bond formation reaction via N-alkylation become one of the current research focuses of organic chemistry. Because water is the only by-product, the N-alkylation of amines with alcohols as alkylating agents is green, environmental, simple and reliable. However, the most of such reactions require a late transition metal catalyst. In this paper the progress in late transition metal-catalyzed N-alkylation reaction with alcohols as alkylating agents starting from various aliphatic, aromatic and heterocyclic aromatic amines in recent years is reviewed. Various homogeneous and heterogeneous catalytic systems as well as the substrate application scope of each method involved in this reaction are mainly introduced. The expectation and development direction about this N-alkylation in future are suggested.

Key words: amine, alcohol, N-alkylation, late transition metal, green chemistry